it depends on the stats i have on the players. eg if i have 88 in middle position and there's 3 people left to act, 2 of which have a vpip of over 30 then its an easy fold whereas if there where 3 left to act and all had a vpip of inbetween say 10 and 20 then i'll play them. generally though most of my hands are played from late position apart from like AA, KK and AK.